| Esterification and Chemoselective Synthesis of R-Tetrahydrothiazo-2-thione-4-carboxylic Esters Catalyzed by TiCl4 |
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| 作者姓名： | SHANG Yan-mei LI Jing SONG Zhi-guang LI Ye-zhi HUANG Hua-min |
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| 作者单位： | SHANG Yan-mei1，LI Jing1，2，SONG Zhi-guang1，LI Ye-zhi1，3 and HUANG Hua-min11.College of Chemistry;2.School of Public Health;3.Key Laboratory for Supermolecular Structure and Materials of Ministry of Education，Jilin University，Changchun 130021，P.R.China |
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| 摘 要： | A series of esters of R-tetrahydrothiazo-2-thione-4-carboxylic acidR-TTCA] was synthesized by direct esterification of R-TTCA with alcohols(CH3OH,C2H5OH,n-C3H7OH,i-C3H7OH,n-C4H9OH,sec-C4H9OH)in the presence of TiCl4 as the catalyst at room temperature without using any other solvent or dehydrant in high yields,91.6%-99.1% for primary alcohols and 55%- 80% for secondary alcohols.The catalyst has a strong chemoselective activity for the esterification of primary alcohols with R-TTCA in the presence of secondary alcohols.Owing to high yield,high chemoselectivity,and mild conditions used,this is an efficient method for the esterification of primary alcohols with R-TTCA.
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| 关 键 词： | 药物合成 催化剂 四氯化钛 化学选择合成 酯化作用 |
| 收稿时间： | 24 November 2006 |
Esterification and Chemoselective Synthesis of R-Tetrahydrothiazo-2- thione-4-carboxylic Esters Catalyzed by TiCl4 |
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| SHANG Yan-mei LI Jing SONG Zhi-guang LI Ye-zhi HUANG Hua-min.Esterification and Chemoselective Synthesis of R-Tetrahydrothiazo-2-thione-4-carboxylic Esters Catalyzed by TiCl4[J].Chemical Research in Chinese University,2007,23(4):430-432. |
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| Authors: | SHANG Yan-mei LI Jing SONG Zhi-guang LI Ye-zhi HUANG Hua-min |
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| Institution: | 1. College of Chemistry, Jilin University, Changchun 130021, P. R. China;2. School of Public Health, Jilin University, Changchun 130021, P. R. China;3. Key Laboratory for Supermolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130021, P. R. China |
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| Abstract: | A series of esters of R-tetrahydrothiazo-2-thione-4-carboxylic acid R-TTCA] was synthesized by direct esterification of R-TTCA with alcohols(CH3OH, C2H5OH, n-C3H7OH, i-C3H7OH, n-C4H9OH, sec-C4H9OH) in the presence of TiCl4 as the catalyst at room temperature without using any other solvent or dehydrant in high yields,91.6%-99.1% for primary alcohols and 55%- 80% for secondary alcohols. The catalyst has a strong chemoselecfive activity for the esterification of primary alcohols with R-TTCA in the presence of secondary alcohols. Owing to high yield, high chemoselectivity, and mild conditions used, this is an efficient method for the esterification of primary alcohols with R-TTCA. |
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| Keywords: | R-Tetrahydrothiazo-2-thione-4-carboxylic acid TiCl4 Chemoselectivity Esterification |
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