(1) Department of Physiology, Sikkim Manipal Institute of Medical Sciences Tadong, 5 Mile, 737102 Gangtok, Sikkim, India;(2) Department of Physiology, University of Calcutta, 92 APC Road, 700009 Kolkata, India
Abstract:
Background
The mechanism of aluminum-induced neurotoxicity is not clear. The involvement of glutamate in the aluminium-induced neurocomplications has been suggested. Brain glutamate levels also found to be altered in protein malnutrition. Alterations in glutamate levels as well as glutamate-α-decarboxylase in different regions of rat brain has been reported in response to aluminum exposure. Thus the study of glutamate metabolising enzymes in different brain regions of rats maintained on either normal or restricted protein diet may be of importance for understanding the neurotoxicity properties of aluminium.
