A very simple, highly stereoselective and modular synthesis of ferrocene-based P-chiral phosphine ligands |
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Authors: | Chen Weiping Mbafor William Roberts Stanley M Whittall John |
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Affiliation: | StylaCats Ltd., Chemistry Department, University of Liverpool, Liverpool L69 7ZD, United Kingdom. weiping.chen@solvias.com |
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Abstract: | A very simple, highly stereoselective and modular synthesis of ferrocene-based P-chiral phosphine ligands has been developed. On the basis of this new methodology, several new families of ferrocene-based phosphine ligands have been prepared coupling chirality at phosphorus with other, more standard stereogenic features. The introduction of P-chirality into ferrocene-based phosphine ligands enhances the enantioselective discrimination produced by the corresponding Rh catalyst when a matching among the planar chirality, carbon chirality, and the chirality of phosphorus is achieved. |
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