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| 3,6-二取代苯基-二-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成 | |
| 引用本文： | 钱建华,刘琳,王道林,邢锦娟.3,6-二取代苯基-二-1,2,4-三唑并[3,4-b]-1,3,4-噻二唑衍生物的合成[J].有机化学,2006,26(12):1720-1722. |
| 作者姓名： | 钱建华 刘琳 王道林 邢锦娟 |
| 作者单位： | 1. 渤海大学应用化学省级重点实验室,锦州,121000;中国科学院金属研究所金属腐蚀与防护国家重点实验室,沈阳,110016 2. 中国科学院金属研究所金属腐蚀与防护国家重点实验室,沈阳,110016 3. 渤海大学应用化学省级重点实验室,锦州,121000 |
| 基金项目： | 教育部科学技术研究重点(No.206029)，辽宁省教育厅(No.05L015)资助项目. |
| 摘 要： | 以2,5-二巯基-1,3,4-噻二唑为原料, 与水合肼缩合, 生成2,5-二肼基-1,3,4-噻二唑. 2,5-二肼基-1,3,4-噻二唑与苯甲酰氯反应生成2,5-二酰肼基-1,3,4-噻二唑, 以POCl3为环合剂环合酰肼基-1,3,4-噻二唑, 合成3,6-二取代苯基- 二-1,2,4-三唑并3,4-b]-1,3,4-噻二唑衍生物, 合成的新化合物的结构通过元素分析、红外光谱、核磁共振氢谱和质谱予以证实, 并提出了环化反应机理. |
| 关 键 词： | POCl3 2 5-二肼基-1 3 4-噻二唑 三唑并1 3 4-噻二唑 反应机理 |
| 收稿时间： | 2006-6-21 |
| 修稿时间： | 2006年6月21日 |
Synthesis of 3,6-Bisubstituted Phenyl-bi-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives |
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| QIAN Jian-Hua,LIU Lin,WANG Dao-Lin,XING Jin-Juan.Synthesis of 3,6-Bisubstituted Phenyl-bi-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole Derivatives[J].Chinese Journal of Organic Chemistry,2006,26(12):1720-1722. | |
| Authors: | QIAN Jian-Hua LIU Lin WANG Dao-Lin XING Jin-Juan |
| Institution: | a. Provincial Key Laboratory for Applied Chemistry, Bohai University, Jinzhou 121000; b. State Key Laboratory for Corrosion and Protection, Institute of Metal Research, Chinese Academy of Sciences, Shenyang 110016 |
| Abstract: | 2,5-Bihydrazino-1,3,4-thiadiazole was synthesized by substitution of 2,5-bimercapto-1,3,4- thiadiazole with hydrazine hydrate and reacted with benzoyl chloride to give 2,5-biacylhydrazino-1,3,4- thiadiazole, which was further ring-closed by POCl3 as cyclization agent to synthesize 3,6-bisubstituted phenyl-bi-1,2,4-triazolo3,4-b]-1,3,4-thiadiazole derivatives. The novel compounds were confirmed by ele- mental analysis, IR, 1H NMR and MS spectra. The mechanism of cycloreaction was also discussed. |
| Keywords: | POCl_3 2 5-bihydrazino-1 3 4-thiadiazol triazolo-1 3 4-thiadiazole mechanism |
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