Preparation and characterization of PVA/SA/HA composite hydrogels for wound dressing |
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| Authors: | Yanzi Jiang Yingjie Hou Wenjuan Liu Yunhui Zhao Tianlong Huang |
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| Institution: | 1. School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, P. R. China;2. Hunan Provincial Key Laboratory of Controllable Preparation and Functional Application of Fine Polymers, Hunan University of Science and Technology, Xiangtan, P. R. China;3. Department of Orthopedics, Second Xiangya Hospital Central South University, Changsha, P. R. China |
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| Abstract: | A composite hydrogel based on, by introducing, polyvinyl alcohol, sodium alginate, and hyaluronic acid was fabricated using CaCl2 as a cross-linker. The physical properties including morphology, water vapor transmission rate, and hydrophilicity were investigated. All PVA/SA/HA composite hydrogels with different compositions had highly homogeneous and interconnected pores, and the morphologies of the PVA/SA/HA hydrogels ranged from fibrous structure to irregular structure with increasing content of SA. The introduction of sodium alginate enhanced the hydrophilicity and water vapor transmission capacity of the hydrogel; however, the hydrophilicity of the composite hydrogels decreased with the increasing cross-linker content. |
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| Keywords: | Polyvinyl alcohol sodium alginate hyaluronic acid wound dressing hydrogel |
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