The potential of biomimetic nanofibrous electrospun scaffold comprising dual component for bone tissue engineering |
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| Authors: | Saravana Kumar Jaganathan Mohan Prasath Mani Gomathi Nageswaran Navaneetha Pandiyaraj Krishnasamy Manikandan Ayyar |
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| Affiliation: | 1. Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Vietnam;2. Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam;3. IJNUTM Cardiovascular Engineering Center, School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, Malaysia;4. School of Biomedical Engineering and Health Sciences, Faculty of Engineering, Universiti Teknologi Malaysia, Skudai, Malaysia;5. Department of Chemistry, Indian Institute of Space Science and Technology, Trivandrum, Kerala, India;6. Surface Engineering Laboratory, Department of Physics, Sri Shakthi Institute of Engineering and Technology, L&7. T by Pass, Chinniyam Palayam, Coimbatore, India;8. Department of Chemistry, Bharath Institute of Higher Education and Research (BIHER), Bharath University, Chennai, Tamil Nadu, India |
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| Abstract: | Oils play a putative choice for alleviating various symptoms associated with bone-related disorders. In this present study, polyurethane (PU) scaffold encompassing with Mahua oil (MO) and propolis (PP) were developed using the electrospinning technique. Morphological analysis showed the reduction in the diameter of the electrospun scaffold with blending of MO and MO/PP into the PU matrix. The strong interactions between PU, MO, and PP were evident through the infrared spectrum and thermal analysis. The wettability results showed the hydrophobic nature in electrospun PU/MO scaffold and hydrophilic behavior in electrospun PU/MO/PP scaffold. Mechanical testing indicated the enhancement in the strength of the PU due to the addition of MO and PP. Moreover, the fabricated scaffolds exhibited nontoxicity, low hemoglobin release and improved blood clotting time as evident in the coagulation studies. The cell proliferation studies showed the enhanced fibroblast cell adhesion in the developed nanocomposites than the pristine PU. Hence, the fabricated PU scaffolds blended with MO and PP having desirable properties can serve as a valuable candidate for bone tissue repair. |
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| Keywords: | Polyurethane Mahua oil/propolis cell adhesion roughness tensile strength |
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