Hypervalent iodine(V) mediated mild and convenient synthesis of substituted 2-amino-1,3,4-oxadiazoles |
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| Authors: | Girish PrabhuV.V. Sureshbabu |
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| Affiliation: | Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Room No. 109, Dr. B. R. Ambedkar Veedhi, Bangalore University, Bangalore 560 001, India |
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| Abstract: | A simple protocol for the synthesis of 2-amino-1,3,4-oxadiazoles starting from the corresponding acylhydrazides by cyclodesulfurization of intermediate acylthiosemicarbazides mediated by o-iodoxybenzoic acid in good yields has been described. The protocol is mild with wide substrate scope, and thus a range of 2-amino-1,3,4-oxadiazoles have been prepared. |
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| Keywords: | Hypervalent iodine reagent IBX Oxadiazole Desulfurization |
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