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Efficient synthetic method of Psammaplin A |
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| Authors: | Suckchang HongMyungmo Lee Myunggi JungYohan Park Mi-hyun KimHyeung-geun Park |
| Institution: | a Research Institute of Pharmaceutical Science and College of Pharmacy, Seoul National University, Seoul 151-742, Republic of Korea b College of Pharmacy, Inje University, 607 Obang-dong, Gimhae, Gyeongnam 621-749, Republic of Korea |
| Abstract: | A new concise and efficient synthetic method of Psammaplin A was developed. Psammaplin A was obtained with 50% overall yield in nine steps from p-hydroxybenzaldehyde and ethyl acetoacetate via Knoevenagel condensation and direct nitrosation as key steps. This method might be very efficient to construct a quite diverse library of Psammaplin A type analogs. |
| Keywords: | Total synthesis Psammaplin A |
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