A scalable approach to diaminopyrazoles using flow chemistry |
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Authors: | Noel S Wilson Augustine T OsumaJennifer AVan Camp Xiangdong Xu |
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Institution: | Medicinal Chemistry Technologies, Global Pharmaceutical Research and Development, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6113, United States |
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Abstract: | This Letter reports on how the combination of microwave and continuous flow chemistry facilitated the convenient preparation of aminopyrazoles from commercial aryl halides. The method was applied to a variety of substrates with good to excellent yields and further extended toward the complete flow synthesis of 5,7-dimethyl-3-phenylpyrazolo1,5-a]pyrimidin-2-amine. |
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Keywords: | Flow chemistry Sequential flow process Aminopyrazole Pyrazolopyrimidine Single mode microwave |
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