| 生物相容性BAB型两亲嵌段共聚物的合成及其自组装 |
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| 引用本文： | 杨子刚,袁建军,程时远. 生物相容性BAB型两亲嵌段共聚物的合成及其自组装[J]. 高分子学报, 2004, 0(6): 903-907 |
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| 作者姓名： | 杨子刚 袁建军 程时远 |
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| 作者单位： | 湖北大学化学与材料科学学院,武汉,430062 |
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| 摘 要： | Lys(z)-NCA was synthesized in the presence of triphosgene, amphiphilic triblock copolymers poly(N^c-CBZ-Lysine)-PEG-poly(N^c-CBZ-Lysine) were synthesized in DMF using amino-end ended PEG as initiator with the mechanism of anion ring opening polymerization. The structures of block copolymers were characterized by IR, ^1H-NMR,GPC and DSC. The results showed triblock copolymers with expected structure and low polydispersity in molecular weight could be synthesized by this method. At the same time, the self-assembling behaviors of block copolymer were investigated by TEM. A novel helical aggregates were found to be formed in DMF. Because of biocompatibility of two components of block copolymers, these block copolymers have potential applications in the field of biomaterials.
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| 关 键 词： | 嵌段共聚物 聚乙二醇 聚(Nε-苄氧羰基赖氨酸) 自组装 螺旋 |
| 修稿时间： | 2004-01-05 |
SYNTHESIS AND SELF-ASSEMBLING OF BIOCOMPATIBLE BAB AMPHIPHILIC TRIBLOCK COPOLYMERS POLY( Nε- CBZ-LYSINE)-PEG-POLY( Nε- CBZ-LYSINE) |
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| YANG Zigang,YUAN Jianjun,CHENG Shiyuan. SYNTHESIS AND SELF-ASSEMBLING OF BIOCOMPATIBLE BAB AMPHIPHILIC TRIBLOCK COPOLYMERS POLY( Nε- CBZ-LYSINE)-PEG-POLY( Nε- CBZ-LYSINE)[J]. Acta Polymerica Sinica, 2004, 0(6): 903-907 |
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| Authors: | YANG Zigang YUAN Jianjun CHENG Shiyuan |
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| Abstract: | Lys(z)-NCA was synthesized in the presence of triphosgene, amphiphilic triblock copolymers poly(N~ε-CBZ-Lysine)-PEG-poly(N~ε-CBZ-Lysine) were synthesized in DMF using amino-end ended PEG as initiator with the mechanism of anion ring opening polymerization. The structures of block copolymers were characterized by IR, ()~1H-NMR,GPC and DSC. The results showed triblock copolymers with expected structure and low polydispersity in molecular weight could be synthesized by this method. At the same time, the self-assembling behaviors of block copolymer were investigated by TEM.A novel helical aggregates were found to be formed in DMF. Because of biocompatibility of two components of block copolymers, these block copolymers have potential applications in the field of biomaterials. |
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| Keywords: | Block copolymers Poly(ethylene glycol) Poly(N+ε-CBZ-Lysine) Self-assembling Helix |
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