Electroreduction and Quantification of Furazolidone and Furaltadone in Different Media

 Adsorptive cathodic stripping voltammetry was used for the determination of furazolidone (FZ) and furaltadone (FD) in borax and phosphate buffers, respectively, using HMDE as working electrode. The influence of different factors upon the peak current response such as accumulation potential, scan rate, preconcentration time, pH and other variables was studied. Furazolidone and furaltadone showed an adsorption character on HMDE in presence of borax and phosphate buffers, respectively. A single cathodic peak at −0.36 V in borax (pH = 9.5) was observed for FZ, while FD gave a cathodic peak at −0.32 V in phosphate buffer (pH = 8.5). The calibration graph showed a linear behavior over the range 3×10⁻⁹–9×10⁻⁸ mol dm⁻³ for furazolidone. In the case of FD, concentrations from 3×10⁻⁹ to 2×10⁻⁷ mol dm⁻³ gave a linear relationship with the peak current. A detection limit of 2×10⁻⁹ mol dm⁻³ and 1×10⁻⁹ mol dm⁻³ was obtained for furazolidone and furaltadone, respectively. This method was applied to determine these drugs in pharmaceutical formulations, urine and serum samples. Received December 15, 1998. Revision February 4, 2000.