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Thio Analogs of Pyrimidine Bases: Synthesis And Spectroscopic Study of New Potentially Biologically Active Disulfides of N,O-(N,N- or O,O-)-Di- and N,N,O-Tri-(o-, m-, and p-)bromobenzyl-2-thiouracils
Authors:Tomasz Pospieszny  Elżbieta Wyrzykiewicz
Institution:Faculty of Chemistry , Adam Mickiewicz University , Poznan, Poland
Abstract:Nine new disulfides of N,O-(N,N- or O,O-)-di- and N,N,O-tri-(o-, m- and p-)bromobenzyl-2-thiouracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, 1H NMR) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of Prediction of Activity Spectra for Substances (PASS).
Keywords:FT-IR  1H NMR  o-(m- and p-)bromobenzyl bromides  Prediction of Activity Spectra for Substances (PASS)  structural isomers  2-thiouracils (2-TU)  UV-Vis
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