Thio Analogs of Pyrimidine Bases: Synthesis And Spectroscopic Study of New Potentially Biologically Active Disulfides of N,O-(N,N- or O,O-)-Di- and N,N,O-Tri-(o-, m-, and p-)bromobenzyl-2-thiouracils |
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Authors: | Tomasz Pospieszny Elżbieta Wyrzykiewicz |
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Institution: | Faculty of Chemistry , Adam Mickiewicz University , Poznan, Poland |
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Abstract: | Nine new disulfides of N,O-(N,N- or O,O-)-di- and N,N,O-tri-(o-, m- and p-)bromobenzyl-2-thiouracils have been prepared. The structures of these compounds were confirmed by spectroscopic (FT-IR, UV-Vis, 1H NMR) and elemental analyses. Estimation of pharmacotherapeutic potential has been made for synthesized compounds on the basis of Prediction of Activity Spectra for Substances (PASS). |
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Keywords: | FT-IR 1H NMR o-(m- and p-)bromobenzyl bromides Prediction of Activity Spectra for Substances (PASS) structural isomers 2-thiouracils (2-TU) UV-Vis |
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