Dapson in Heterocyclic Chemistry,Part I: Novel Synthesis of Sulfone Biscompounds for Antimicrobial and Antitumor Activities |
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| Authors: | M. M. Ghorab N. M. H. Taha M. A. A. Radwan N. E. Amin M. A. Shehab I. M. I. Faker |
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| Affiliation: | 1. Department of Drug Radiation Research , National Center for Radiation Research and Technology (NCRRT) , Nasr City, Cairo, Egypt;2. Organic Chemistry Department, Faculty of Science for Girls , Al-Azhar University , Cairo, Egypt;3. Applied Organic Chemistry Department , National Research Center , Cairo, Egypt |
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| Abstract: | This article describes the synthesis of some novel sulfone bis-compounds bearing the biologically active thioether 3–6 ; thioureido 7, 8, 15, 16; triazole 10, 11; thiosemicarbazido 9, 12, 13; and 1,3,4-thiadiazole 14, 17 moieties starting with 4,4′-diisothiocyanato-1,1-diphenylsulfone 2. The structures of newly synthesized compounds were confirmed by elemental analysis, IR, 1 H-NMR and mass spectral data. Compound 3 was found to be the most active compound against Escherichia coli. Also, compound 15 acted as potent cytotoxic agent. |
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| Keywords: | Antimicrobial and antitumor agents sulfone derivatives |
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