Synthesis of 5-(7-Hydroxyheptyl)-1,2-dithiolan-3-one 1-Oxide,a Core Functionality of Antibiotic Leinamycin |
| |
Authors: | Alex H. F. Lee Jian Chen Albert S. C. Chan Tianhu Li |
| |
Affiliation: | Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong |
| |
Abstract: | 5-(7-Hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was designed and synthesized in our laboratories that contain the heterocycle of 1,2-dithiolan-3-one 1-oxide, a reactive core of antibiotic leinamycin. In addition, the activated ester of 5-(7-hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was prepared, which presumably is useful for coupling this DNA-cleaving functionality to certain DNA-binding agents. |
| |
Keywords: | Antibiotic Antitumor Agents Heterocycle Leinamycin |
|
|