Synthesis of 5-(7-Hydroxyheptyl)-1,2-dithiolan-3-one 1-Oxide,a Core Functionality of Antibiotic Leinamycin |
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| Authors: | Alex H F Lee Jian Chen Albert S C Chan Tianhu Li |
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| Institution: | Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong |
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| Abstract: | 5-(7-Hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was designed and synthesized in our laboratories that contain the heterocycle of 1,2-dithiolan-3-one 1-oxide, a reactive core of antibiotic leinamycin. In addition, the activated ester of 5-(7-hydroxyheptyl)-1,2-dithiolan-3-one 1-oxide was prepared, which presumably is useful for coupling this DNA-cleaving functionality to certain DNA-binding agents. |
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| Keywords: | Antibiotic Antitumor Agents Heterocycle Leinamycin |
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