Synthesis and Characterization of Some Novel 3-Bromo-2-acetylthiophene Chalcones and Biological Evaluation of Their Ethyl-4-(3-bromothien-2-yl)-2-oxo-6-(aryl)cyclohex-3-ene-1-carboxylate Derivatives |
| |
| Authors: | B V Ashalatha B Narayana K K Vijaya Raj |
| |
| Institution: | Department of Post-Graduate Studies and Research in Chemistry , Mangalore University , Mangalagangotri, India |
| |
| Abstract: | Novel chalcones 1-(3-bromothien-2-yl)-3-(aryl)prop-2-en-1-ones derived from 3-bromo-2-acetylthiophene and their cyclization product with ethylacetoacetate such as 4-(3-bromothien-2-yl)-2-oxo-6-(aryl)cyclohex-3-ene-1-carboxylate derivatives were synthesized and studied by X-ray, analytical, and spectral methods. Compounds were screened for their anti-inflammatory, analgesic, and antimicrobial activities. The compound ethyl-4-(3-bromothien-2-yl)-2-oxo-6-(4-propoxyphenyl) cyclohex-3-ene-1-carboxylate 5c exhibited promising anti-inflammatory, analgesic and antibacterial activities. |
| |
| Keywords: | Biological evaluation 3-bromo-2-acetylthiophene chalcones characterization cyclohex-3-ene-1-carboxylate synthesis |
|
|
