A Mild,Simple, Efficient,and Selective Protection of Hydroxyl Groups Using Silica-Supported Sodium Hydrogen Sulfate as a Heterogeneous Catalyst |
| |
| Authors: | Hamid Reza Shaterian Razieh Doostmohammadi Majid Ghashang Mashaallah Rahmani |
| |
| Institution: | Department of Chemistry, Faculty of Sciences , University of Sistan and Baluchestan , Zahedan, Iran |
| |
| Abstract: | A mild, simple, novel, and highly efficient method for the rapid protection of various primary, secondary, tertiary aliphatic alcohols, aromatic alcohols, and oximes using hexamethyldisilazane (HMDS) in the presence of silica-supported sodium hydrogen sulfate (NaHSO 4 -SiO 2 ), as an active, inexpensive, nontoxic, heterogeneous, and readily available catalyst under ambient conditions is described. Timethylsilyl ethers were prepared in high to excellent yields, with short reaction times under mild and almost neutral reaction conditions at room temperature. |
| |
| Keywords: | Alcohol heterogeneous catalyst hexamethyldisilazane NaHSO4-SiO2 oxime silylation |
|
|
