SYNTHESIS OF NOVEL SULPHONAMIDES AND EVALUATION OF THEIR ANTIBACTERIAL EFFICACY |
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Authors: | H. S. Patel H. J. Mistry |
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Affiliation: | Sardar Patel University , Vallabh Vidyanagar, Gujarat, India |
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Abstract: | 4-(4′-sulphanilyl)-1-phenyl pipearzine (2) has been prepared by ther reaction of N-acetyl sulphanilyl chloride (ASC) with 1-phenyl piperazine followed by the hydrolysis of the product by ethanolic HCl. The hydrolyze product on facile condensation reaction with aromatic aldehydes yields Schiff bases/anils/azomethines (3a–h). These anils on cyclo condensation reaction with chloro acetyl chloride and thio glycolic acid (mercapto acetic acid) yields 2-azetidinones and 4-thiazolidinones respectively. Biological screening of the prepared compounds have been screened on some strains of bacteria. |
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Keywords: | 2-Azetidinones 4-thiazoidinones cyclo-condensation reaction facile condensation N-acetyl sulphanilyl chloride |
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