Isocoumarin Thioanalogues as Potential Antibacterial Agents |
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| Authors: | P. Manivel S. Mohana Roopan D. Prem Kumar F. Nawaz Khan |
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| Affiliation: | 1. Organic and Inorganic Chemistry Division, School of Science and Humanities , VIT University , Vellore, Tamil Nadu, India;2. Syngene International Limited , Bangalore, Karnataka, India;3. Organic and Inorganic Chemistry Division, School of Science and Humanities , VIT University , Vellore, Tamil Nadu, India |
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| Abstract: | A series of 3-substituted-1H-isochromene-1-thiones (3) were prepared by the reaction of 3-substituted isocoumarins (2) with Lawesson's reagent in the presence of toluene under a nitrogen atmosphere. The antimicrobial activities of the newly synthesized products were measured using Gram-negative (Escherichia coli, Salmonella typhi, and Proteus mirabilis) and Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus). Synthesized thioanalogue of isocoumarins showed good antibacterial activity against Proteus mirabilis. |
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| Keywords: | Isochromene-1-thione isocoumarins Lawesson's reagent |
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