Synthesis of Phosphonoindoprofen |
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| Authors: | Georgiy O. Kachkovskyi Oleg I. Kolodiazhnyi |
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| Affiliation: | Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine , Kyiv , Ukraine |
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| Abstract: | Two synthetic routes to phosphonic analogues of indoprofen, a nonsteroidal anti-inflammatory drug, were developed by the cyclization of aniline 2 (method A) and by the Arbuzov reaction of corresponding alkylchloride 3 with triethylphosphite (method B). |
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| Keywords: | Indoprofen isoindolin-1-ones phosphonic acids |
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