A One-Pot Synthesis of Thiophenes and Their Annulated Derivatives With Potential Pharmaceutical Interest

The reaction of 2-cyanomethylene benzod]imidazole (1) with carbon disulphide in basic DMF solution gave the di-potassium disulphide salt (3). The reaction of the latter with the α -halocarbonyl compounds 4 and 13 afforded the thiophene derivatives 5 and 14, respectively. The latter products were used to synthesize annulated products with potential pharmaceutical interest.