Synthesis and Blood Glucose Lowering Activity of Novel Benzenesulfonyl-Urea Derivatives |
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Authors: | Shamim Ahmad Kalim Javed I G Rathish Sameena Bano M S Alam |
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Institution: | Department of Chemistry, Faculty of Science , Jamia Hamdard (Hamdard University) , New Delhi, India |
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Abstract: | Treatment of the pyridazinone derivatives ( 1a, 1b ) with ethyl chloroformate afforded novel carbamates ( 2a, 2b ). Subsequent treatment of 2a, 2b with appropriate amines gave novel benzenesulfonylurea derivatives ( 3a–i ). All these compounds were characterized on the basis of 1 H NMR, IR, Mass spectral data and elemental analysis results. Preliminary biological testing of urea derivatives revealed that some compounds possess significant blood sugar lowering activity. Four compounds ( 3c, 3f, 3g , and 3h ) were found to have promising blood glucose lowering activity and may be used as lead compounds for developing new antidiabetic drugs. |
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Keywords: | Benzenesulfonylurea carbamates diabetes pyridazinones |
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