Tetrachlorosilane-Zinc Chloride as a New Potent Binary Reagent for One-Pot,Three-Component Synthesis of Mannich-Type Products |
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| Authors: | Doria S. Badawy Ebrahim Abdel-Galil Ezzat M. Kandeel Wahid M. Basyouni Tamer K. Khatab |
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| Affiliation: | 1. Chemistry Department, Faculty of Science , Mansoura University , Mansoura, Egypt;2. Organometallic and Organometalloid Chemistry Department , National Research Centre , Dokki, Cairo, Egypt |
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| Abstract: | A combination of tetrachlorosilane and zinc chloride in dichloromethane as an efficient and ambient binary reagent to promote a one-pot amidoalkylation reaction of enolizable ketones, aromatic aldehydes with acetonitriles, or benzonitrile have been developed. The newly synthesized β-acetamidoketones 3 and β-benzamidoketones 5 were obtained in good yields. |
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| Keywords: | β-Acylaminoeketones amidoalkylation binary reagent multicomponent naphthyl tetrachlorosilane |
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