The Synthesis of Some Pyrazolyl- and Thiazolylthienopyridines |
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Authors: | A M Kamal El-Dean A A Geies Y A El-Ossaily |
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Institution: | Chemistry Department , Assiut University , Assiut , Egypt |
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Abstract: | 2-acetyl-3-amino-4,6-dimethylthieno2,3-b]pyridine 1 reacted with dimethoxy-tetrahydrofuran in acetic acid and ethyl cyanoacetate in the presence of ammonium acetate or with NaNO2 in the presence of an AcOH/HCl mixture to produce 2–4. Compound 2 reacted with aromatic aldehydes, semicarbazide hydrochloride, thiosemicarbazide, and phenyl hydrazine or with hydrazine hydrate to give compounds 5a–c and 11a–d, respectively. Chalcone 5 reacted with hydrazines, hydroxylamine hydrochloride, or thiourea to produce compounds 6–9. Thiosemicarbazone 11b reacted with α -haloester to produce the corresponding thiazolidinone derivatives 12a, b ; also it reacted with ω -bromoacetophenone to give thiazoline derivatives 13a, b . |
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Keywords: | Pyrrolylthiazolylthienopyridines pyrrolylthienopyridines thienopyridines |
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