Green Protocol for the Synthesis of Bisindolylmethanes and Evaluation of Their Antimicrobial Activities |
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Authors: | Anjali Tiwari Meenakshi Jain |
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Institution: | Centre of Advanced Studies, Department of Chemistry , University of Rajasthan , Jaipur, India |
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Abstract: | A simple, efficient, and ecofriendly procedure for the preparation of bis(indolyl)methanes via electrophilic substitution reactions of 2-phenylindoles with aldehydes is described. The reaction takes place in the presence of glacial acetic acid and a catalytic amount of anhydrous ferric chloride. All the synthesized compounds have been characterized by elemental analysis and spectral data (IR and 1H NMR). They have also been evaluated for their antibacterial and antifungal activities, and some of them have shown promising results against S. aureus, E. coli, A. flavus, and A. niger. |
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Keywords: | Anhydrous ferric chloride bis(indolyl)methanes ecofriendly procedure electrophilic substitution reaction green chemistry techniques 2-phenylindole |
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