A Convenient Preparation of 2-(2-Arylidene)- and 2-(2-Polyhydroxyalkylidene)hydrazono-4-imidazolidinones with Various Heterocyclic Side Chain Substituents at Position 5 as Potential Antiviral and Antitumor Agents |
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Authors: | Ahmed I Khodair |
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Institution: | Chemistry Department, Faculty of Education , Tanta University , Kafr El-Sheikh Branch, Kafr El-Sheikh , Egypt |
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Abstract: | A variety of novel 5-( Z )-arylidene]-2-(2-( E )-arylidene)hydrazono]-4-imidazolidinones 1a-c to 4a , b and 5-( Z )-arylidene]-2-(2-( E )-polyhydroxyalkylidene)hydrazono]-4-imidazolidinones 5a-c to 7a-c were prepared from the reaction of 5-( Z )-arylidene]-2-methylmercaptohydantoins 8a-c with 2-( E )-arylidene hydrazones 13a-d and/or 2-( E )-monosaccharides hydrazones 16a-c . The linear structure, and not that of the angular isomer, has been selected for the products. This structure has been confirmed from a model study of the condensation of 5-( Z )-2-thienylidene]-2-hydrazono-4-imidazolidinone 9a with benzaldehyde and D -galactose, respectively. The acetylation and benzoylation reactions of compounds 1-7 have been studied. All the new compounds were tested for their potential antiviral and antitumor activities. |
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Keywords: | Antitumor Agents Antiviral 2-( E )-Monosaccharides Hydrazones 5-[( Z )-arylidene]-2-methylmercaptohydantoins 5-[( Z )-(arylidene]-2-[(2-( E )-polyhydroxyalkylidene)hydrazono]-4-imidazolidinones |
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