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Chiral 2-(2-Diphenylphosphinophenyl)-oxazolines: Synthesis and Use in Pd-Catalyzed Asymmetric Allylic Alkylation |
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| Authors: | Benjamin Ganchegui Carole Chevrin Sandrine Bouquillon Jean Le Bras Françoise Hénin Jacques Muzart |
| Affiliation: | Unité Mixte de Recherche “Réactions Sélectives et Applications,” CNRS Université de Reims Champagne–Ardenne , France |
| Abstract: | The synthesis of 2-(2-diphenylphosphinophenyl)-oxazolines from o-fluoroben-zonitrile and (-)-norephedrine or (+)-endo-2-hydroxy-endo-3-aminobornane is described. The Pa-catalyzed alkylation of (E)-1,3-diphenylallyl acetate with the sodium salt of dimethylmalonate using these chiral ligands occurs with an 82–87% yield and 88–93% ee. |
| Keywords: | η3-allylpalladium allylic alkylation asymmetry catalysis oxazolines |