Total Synthesis of Polypropionate Natural Products: Application of New Sulfur Dioxide Chemistry |
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| Authors: | C Craita L Bouchez M Turks X Huang F Fonquerne M C Murcia |
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| Institution: | Laboratory of Glycochemistry and Asymmetric Synthesis, Swiss Federal Institute of Technology Lausanne , Lausanne-Dorigny, Switzerland |
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| Abstract: | Abstract In the presence of a Lewis or protic acid at low temperature, electron-rich dienes add to sulfur dioxide and carbon nucleophiles generating silyl sulfinates. The latter can be transformed into valuable polyketide precursors. |
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| Keywords: | Polypropionate retro-ene reaction sulfur dioxide umpolung with SO2 |
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