Reactions of Cyanothioacetamide: Synthesis of Several New Thioxohydro-pyridine-3-carbonitrile and Thieno[2,3-b]pyridine Derivatives |
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Authors: | Fawzy A. Attaby Sanaa M. Eldin Mohamed A. A. Elneairy Ali K. K. El-Louh |
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Affiliation: | Department of Pesticidal Chemistry, National Research Center , Giza, Egypt |
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Abstract: | Cyanothioacetamide (f 1) reacted with α,β -unsaturated carbonyl compounds 2a–d to afford thioxohydropyridine-3-carbonitriles 5a–d, which were used as the starting materials for the preparation of several thienopyridines via their reactions with active halogen-containing compounds, e.g., 2-bromo-1-phenylethanone (7a), 2-bromo-1-p-tolyl-ethanone (7b), chloroacetone (10a), α -chloroacetylacetone (10b), and chloroacetic acid ethyl ester (13). The structure of the newly synthesized heterocyclic compounds were established based on the data of elemental analyses, IR, 1 H NMR, and mass spectra. |
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Keywords: | 2-Methylthio-pyridines 2-oxopropylthiopyridines 3-aminothieno[2,3-b]pyridines cyanothioacetamide thioxohydropyridines |
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