NEW AND CONVENIENT SYNTHESIS OF (R) AND (S) OF 2-METHYL-3-OXA-5-(TERT-BUTYLDIPHENYLSILYLOXYL) METHYLPENTANOATE AND 2-METHYL-3-OXA-5- (TERT-BUTYLDIMETHYLSILYLOXYL)METHYLPENTANOATE |
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| Authors: | Abdel-Sattar S Hamad Dieter Schinzer |
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| Institution: | 1. Department of Chemistry, Faculty of Science , University of Ain Shams , Abbassia, 11566 , Cairo , Egypt;2. Chemisches Institut der Otto-von-Guericke-Universitat magdeburg, Universitatsplatz , 2D-39106 , Magdeburg , Germany |
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| Abstract: | Abstract (R) and (S) of 2-Methy1-3-oxa-5-(tert-butyldiphenylsilyloxyl)methy1pentanoate (4a. 6a) and (R) and (S) of 2-methy1-3-oxa-5-(tert-butyldimethylsilyloxyl)methylpentanoate (4b, 6b) were synthesized by the reaction of the preparative compounds (2a, 2b) with (R) and (S) methy1lactate (3, 4) in the presence of a silver (1) oxide catalyst (Method B). The title compounds are useful for the synthesis of different natural products such as epothilones. |
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| Keywords: | Epothilones Natural Products silylation Etherification Organosilicon |
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