Synthesis of New Tetraethyl(N-alkyl-1-aminoethan-1,1-diyl)bisphosphona-tes and ESR Analysis of Chemical Exchange of Derived Nitroxides of Acyclic Aminobisphosphonates |
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| Authors: | Gilles Olive Antal Rockenbauer Xavier Rozanska Alain Jacques Daniel Peeters Anton German |
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| Affiliation: | 1. Department of Polymer Chemistry and Coatings Technology , Eindhoven University of Technology , Eindhoven , The Netherlands;2. Schuit Institute of Catalysis, Laboratory of Inorganic Chemistry and Catalysis, Eindhoven University of Technology , Eindhoven , The Netherlands;3. Unité CSTR , Université Catholique de Louvain , Batiment Lavoisier, Louvain-la-Nueve , Belgium |
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| Abstract: | The synthesis and the full characterization of two new linear bisphosphonates (tetraethyl(N-tert-butyl-1-aminoethan-1,1-diyl)bisphosphonate and tetraethyl(N-sec-butyl-1-aminoethan-1,1-diyl)bisphosphonate), and the first analysis of the ESR spectra of the corresponding nitroxides is reported. The preliminary results of theoretical calculations on model compounds suggest a small B0 (in the McConnell equation). The results of bisphosphonate ester and bisphosphonic acid are similar. The discrepancies of P coupling for the diphosphorus compound stems from B2 that is different when the dihedral angle is larger than 90°. |
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| Keywords: | Bisphosphonates diphosphorylation ESR McConnell equation nitroxide theoretical calculations |
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