A CONVENIENT METHOD FOR THE SYNTHESIS OF PHOSPHOROTHIOATES AND THEIR ANTICHOLINESTERASE ACTIVITIES |
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| Authors: | Babak Kaboudin Saeed Emadi Hamid Norouzi |
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| Affiliation: | Institute for Advanced Studies in Basic Sciences , Zanjan, Iran |
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| Abstract: | A simple, efficient, and general method has been developed for the synthesis of phosphorothioates through a one-pot reaction of alkyl halides with the mixture of diethyl phosphite in the presence of NH 4 OAc/S/CaO under solvent–free conditions. The anticholinesterase activities of eight different phosphorothioates were investigated on acetylcholinesterase from electric eel. |
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| Keywords: | Ammonium acetate anticholinesterase activity calcium oxide phosphorothioate sulfur |
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