SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

Abstract

2-Thioxc-3,5,7-trisubstitutcd-I-2′.3′,5′-tri-O-benzoyl-β-D-ribofuranosyllpyrido 2,3-d]pyri midin-4(IH)-ones have been prepared by the condensation of trimethylsilyl derivative of 2-thioxo-3,5,7-trisubstituted pyrido2,3-d]pyrimidin-4(IH)-ones with β-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by IR, ¹H NMR and elemental analysis. These derivatives have been screened for their antimicrobial activity.