Synthesis and Antitumor Evaluation of Some Newly Synthesized Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives |
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Authors: | Aymn E. Rashad Mohamed I. Hegab Randa E. Abdel-Megeid Mamdouh M. Ali Farouk M. E. Abdel-Megeid |
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Affiliation: | 1. Photochemistry Department , National Research Centre , Dokki, Cairo, Egypt;2. Biochemistry Department , National Research Centre , Dokki, Cairo, Egypt |
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Abstract: | A series of novel pyrazolo[3,4-d]pyrimidine 2b, 3, 5b, pyrazolotetrazolopyrimidine 4, and pyrazolotriazolopyrimidine derivatives 6a,b–10a,b have been synthesized and characterized by elemental analysis and spectroscopic data. Furthermore, the cytotoxicity and in vivo antitumor evaluation of some prepared compounds have been assessed, and derivatives 1a and 6b revealed promising activity in comparison to that of Cisplatin. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. |
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Keywords: | Antitumor activity pyrazolo[3,4-d]pyrimidine pyrazolotetrazolopyrimidine pyrazolotriazolopyrimidine |
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