The Synthesis of 2-(5-(Aryloxymethyl)-1,3,4-thiadiazol-2-ylthio)-N-arylacetamides at Room Temperature via Grinding |
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| Authors: | Xi-Cun Wang Sheng-Qing Wang Xiao-Mei Ding Xue-Fei Chen |
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| Institution: | 1. Key Laboratory of Eco-Environment-Related Polymer Materials , Ministry of Education , Lanzhou, Gansu, China;2. Gansu Key Laboratory of Polymer Materials , College of Chemistry and Chemical Engineering, Northwest Normal University , Lanzhou, Gansu, China |
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| Abstract: | Fifteen 2-(5-(aryloxymethyl)-1,3,4-thiadiazol-2-ylthio)-N-arylacetamides were efficiently synthesized from the reaction of 2-chloro-N-arylacetamide with 5-(aryloxymethyl)-1,3,4-thiadiazole-2-thiol under solvent-free conditions at room temperature via grinding. The key advantages of the method are the short reaction time, high yields, simple workup, and environmentally friendly conditions compared to conventional heating. |
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| Keywords: | Acetamides grinding synthesis 1 3 4-thiadiazoles |
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