Heteroaromatization with Sulfonamido Phenyl Ethanone,Part I: Synthesis of Novel Pyrrolo[2,3-D]Pyrimidine and Pyrrolo[3,2-E][1,2,4]Triazolo[1,5-C]Pyrimidine Derivatives Containing Dimethylsulfonamide Moiety |
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Authors: | Saber M Hassan Ahmed A El-Maghraby Mahmoud M Abdel Aal Mahmoud S Bashandy |
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Institution: | Chemistry Department, Faculty of Science , Al-Azhar University , Nasr City, Cairo, Egypt |
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Abstract: | 4-(5-Amino-4-cyano-1-p-tolyl-1H-pyrrol-3-yl)-N,N-dimethyl-benzenesulfonamide (4) was prepared and converted to several pyrrolo2,3-d]pyrimidin-5-yl)-N,N-dimethyl-benzenesulfonamide derivatives (5,7,9, and 13). Cyclocondensation of 13 with different electrophilic carbon reagents afforded several 4-(N,N-dimethylaminosulfonylphenyl)]pyrrolo3,2-e]1,2,4]triazolo1,5-c]-pyrimidine derivatives (14–17,19, and 20); IR, 1HNMR, and mass spectra of the newly synthesized compounds were recorded. Most of the obtained compounds were screened against Gram-positive and Gram-negative bacteria and fungi, for which some of these derivatives gave promising results. |
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Keywords: | Antimicrobial and antifungal activities 4-(2-bromoacetyl)-N N-dimethyl-benzenesulfonamide 4-(N N-dimethylaminosulfonylphenyl)]pyrrolo[3 2-e][1 2 4]triazolo-[1 5-c]pyrimidines pyrrolo[2 3-d] pyrimidin-5-yl)-N N-dimethyl-benzenesulfonamide |
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