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Heteroaromatization with Sulfonamido Phenyl Ethanone,Part I: Synthesis of Novel Pyrrolo[2,3-D]Pyrimidine and Pyrrolo[3,2-E][1,2,4]Triazolo[1,5-C]Pyrimidine Derivatives Containing Dimethylsulfonamide Moiety
Authors:Saber M Hassan  Ahmed A El-Maghraby  Mahmoud M Abdel Aal  Mahmoud S Bashandy
Institution:Chemistry Department, Faculty of Science , Al-Azhar University , Nasr City, Cairo, Egypt
Abstract:4-(5-Amino-4-cyano-1-p-tolyl-1H-pyrrol-3-yl)-N,N-dimethyl-benzenesulfonamide (4) was prepared and converted to several pyrrolo2,3-d]pyrimidin-5-yl)-N,N-dimethyl-benzenesulfonamide derivatives (5,7,9, and 13). Cyclocondensation of 13 with different electrophilic carbon reagents afforded several 4-(N,N-dimethylaminosulfonylphenyl)]pyrrolo3,2-e]1,2,4]triazolo1,5-c]-pyrimidine derivatives (14–17,19, and 20); IR, 1HNMR, and mass spectra of the newly synthesized compounds were recorded. Most of the obtained compounds were screened against Gram-positive and Gram-negative bacteria and fungi, for which some of these derivatives gave promising results.
Keywords:Antimicrobial and antifungal activities  4-(2-bromoacetyl)-N  N-dimethyl-benzenesulfonamide  4-(N  N-dimethylaminosulfonylphenyl)]pyrrolo[3  2-e][1  2  4]triazolo-[1  5-c]pyrimidines  pyrrolo[2  3-d] pyrimidin-5-yl)-N  N-dimethyl-benzenesulfonamide
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