Stereoselective Synthesis of Phosphorus Analogs of (R)-Carnitine and (R)-Gabob |
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| Authors: | Cheng-ye Yuan Ke Wang Jinfeng Li Zu-yi Li |
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| Institution: | Shanghai Institute of Organic Chemistry , Chinese Academy of Science , Shanghai, China |
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| Abstract: | Bioreduction of 3-substituted-2-oxoalkanephosphonates by baker's yeast afforded corresponding 2-hydroxy-alkanephosphonates in good yields and ee value. These compounds ( 2a,b ) could serve as useful chirons for the stereoselective synthesis of phosphorus analogs of (R)-Carnitine and (R)-GABOB. |
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| Keywords: | Baker's Yeast Bioreduction Hydroxyphosphonates |
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