Unexpected Rearrangement of Diethyl (±)(S,S)-1,2-epoxy-2-Phenylpentylphosphonate by NH 3(aqu.) : An Easy Entry to Ethyl 1-Formyl-1-Phenylbutylphosphonate |
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| Authors: | Marcin Drag Pawel Kafarski Jean-Luc Pirat Henri-Jean Cristau |
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| Institution: | 1. Institute of Organic Chemistry , University of Technology , Wroclaw , Poland;2. Laboratoire de Chimie Organique , Ecole Nationale Supérieure de Chimie de Montpellier , France;3. Institute of Organic Chemistry , University of Technology , Wroclaw , Poland;4. Laboratoire de Chimie Organique , Ecole Nationale Supérieure de Chimie de Montpellier , France |
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| Abstract: | A simple reaction of diethyl ( - )(S,S)-1,2-epoxy-2-phenylpentylphosphonate with 28% NH 3(aqu.) in MeOH led to the ethyl 1-formyl-1-phenylbutylphosphonate in excellent yield. The procedure consists simply in stirring the substrate and 28% NH 3(aqu.) in MeOH, at 40;C. |
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| Keywords: | 1-formylmethylphosphonate 1 2-epoxy Phosphonic Ester Rearrangement |
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