Synthesis and Biological Evaluation of Novel Tetracyclic Benzothiazepines |
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| Authors: | T. Apparao V. Peesapati G. Rupavani S. Ramakrishna |
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| Affiliation: | 1. Industrial Chemistry Laboratory, Centre for Environment, Institute of Science Technology , JNT University , Hyderabad, India;2. Postgraduate College of Sciences , Palamur University , Mehaboob Nagar, A.P., India;3. Pharmacology Division , Indian Institute of Chemical Technology , Hyderabad, India |
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| Abstract: | 6-Arylidene-2,3-dimethyl-6,7,8,9-tetrahydro-benzocyclohepten-5-one 2a–l were obtained by the condensation of 2,3-dimethyl/3-methyl benzocyclohepten-5-one 1 with appropriate aromatic aldehydes, and upon condensation with 2-aminothiophenol in ethyl alcohol yielded 1,5-benzothiazepine derivatives 3a–l, respectively. Compounds 3d and 3h were found to possess antimicrobial activity when tested against B. Subtilis. Compounds 3i and 3j were found to possess moderate anti-inflammatory activity. Compound 3b was found to possess comparable antifungal activity when compared to clotrimazole against Trichomonas species. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. |
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| Keywords: | Antibacterial, anti-inflammatory, and antifungal activities aromatic aldehydes benzocyclohepten-5-one 1,5-benzothiazepines |
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