Allenes through Horner-Wadsworth-Emmons Olefination of Alkenylphosphonates |
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| Authors: | Yasuo Nagaoka Hideki Inoue Kiyoshi Tomioka |
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| Institution: | Graduate School of Pharmaceutical Sciences , Kyoto University , Yoshida, Sakyo-ku, Kyoto , Japan |
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| Abstract: | Mono- and di-substituted allenes 5 were synthesized by successive Horner-Wadsworth-Emmons olefination starting from methylene-bisphosphonate 1 and two carbonyl compounds. The key to success is KH or KH-18-crown-6 as a base for the second HWE olefination of hydroxyalkenylphosphonates 4 . |
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| Keywords: | Allene 18-crown-6 Double Olefination Horner-Wadsworth-Emmons Reaction Phosphonate |
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