Synthesis and Characterization of New Thiazolidin-4-one Derivatives |
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Authors: | Bao Xiang Hu Zhen Lu Shen Jun Lu Xin Quan Hu Wei Min Mo Nan Sun |
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Institution: | College of Chemical Engineering and Materials Science , Zhejiang University of Technology , Hangzhou, Zhejiang, China |
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Abstract: | The synthesis of some new functionalized thiazolidin-4-one derivatives has been described. The N-substituted-thiosemicarbazides 3a-3i were obtained though the reaction of alkylamines 2a–2i , carbon disulfide, and hydrazine hydrate. The condensation reaction between 3a–3i and 4-amino-2-methanesulfanylpyrimidine-5-carboxaldehyde 1 afforded the thiosemicarbazones 4a–4i . The corresponding thiazolidin-4-ones 5a–5i were prepared by cyclization of 4a–4i with ethyl bromoacetate. The structures of the final products were confirmed by IR, 1 H NMR, 13 C NMR, and HRMS. |
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Keywords: | 4-Amino-2-methanesulfanylpyrimidine-5-carboxaldehyde thiazolidin-4-ones thiosemicarbazides thiosemicarbazones |
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