Radioprotective and Antitumor Activity of Some Novel Amino Acids and Imidazoles Containing Thieno[2,3-d]pyrimidine Moiety |
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| Authors: | Saleh I Alqasoumi Fatma A Ragab Ahmed M Alafeefy Marwa Galal Mostafa M Ghorab |
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| Institution: | 1. Medicinal, Aromatic and Poisonous Plants Research Center (MAPPRC) , College of Pharmacy, King Saud University , Saudi Arabia;2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy , Cairo University , Cairo, Egypt;3. Department of Pharmaceutical Chemistry , College of Pharmacy, King Saud University , Saudi Arabia |
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| Abstract: | A variety of novel thieno2,3-d]pyrimidine derivatives, comprising amino acids 3a–l, imidazothieno-pyrimidines 4A, 4b–h, and 7, were obtained via the reaction of 4-chloro-5,6-dimethylthieno2,3-d]pyrimidine 1 with a variety of reagents. The structures of these compounds were confirmed by microanalysis, IR, 1H NMR, and mass spectrometry. Some of the obtained compounds showed promising radioprotective and antitumor activities. |
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| Keywords: | Amino acids antitumor radioprotective thieno[2 3-d]pyrimidines |
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