Microwave-Assisted Synthesis of Some Bi- and Tricyclic Pyrimidine Derivatives |
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Authors: | N Foroughifar A Mobinikhaledi H Fathinejad Jirandehi S Memar |
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Institution: | Arak University , Arak, Iran |
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Abstract: | Pyrimidine derivatives 4a-4c was prepared by a Biginelli cyclocondensation of g -ketoesters, aryl aldehydes, and thiourea derivatives under microwave irradiation. A simple and fast synthesis of bicyclic pyrimidine derivatives 6a-6c was performed by microwave-assisted reaction of 4a-4c with bromomalononitrile ( 5 ). Reaction of bicyclic pyrimidines 6a-6c with HCO 2 H and HONH 3 Cl under microwave irradiation gave tricyclic pyrimidines 7a-7c and 8a-8c respectively. |
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Keywords: | Bromomalononitrile Microwave Neutral Alumina Pyrimidine |
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