Preparation of Some Thiazolyl Hydrazone Derivatives and Evaluation of Their Antibacterial Activities |
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Authors: | Gülhan Turan-Zitouni Ahmet Özdemir Zafer Asım Kaplancıklı Jean-Alain Fehrentz Jean Martinez Pierre Chevallet |
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Institution: | 1. Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Eski?ehir, Turkey;2. Institut des Biomolécules Max Mousseron , CNRS-Université Montpellier 1 et 2, Faculté de Pharmacie , UMR 5247, Montpellier Cedex, France |
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Abstract: | The increasing clinical importance of drug-resistant fungal and bacterial pathogens has provided additional urgency to microbiological research and to the development of new antibacterial compounds. For this purpose, new tert-butyl 1-aryl/alkyl-2(4-aryl-2-thiazolyl)hydrazono]ethyl]carbamate derivatives were synthesized and evaluated for antibacterial activity. The reaction of Boc-L-phenylalaninal, Boc-D-phenylalaninal, Boc-L-leucinal, and Boc-L-tryptophanal with thiosemicarbazide yielded the thiosemicarbazones, which furnished the title compounds on reaction with phenacyl bromides. The new compounds were screened for antibacterial activity. The results from the bioassay tests show that some of the compounds have notable activity against Gram-positive bacteria. |
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Keywords: | Amino acid antibacterial activity thiazole |
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