Synthesis of Substituted Pyrazino[5,6-b]pyrimidine and Some Indole Derivatives |
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| Authors: | Navabeh Nami Masoumeh Hosseinzadeh Nasrin Nami Mina Haghdadi |
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| Affiliation: | 1. Department of Chemistry , Islamic Azad University , Ghaemshahr, Mazandaran, Iran;2. Department of Chemistry , Islamic Azad University , Amol, Mazandaran, Iran;3. Department of Chemistry , Islamic Azad University , Babol, Mazandaran, Iran |
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| Abstract: | Refluxing dimethyl acetylenedicarboxylate (DMAD) or 1,2-dibenzoylacetylene with isatin-3-thiosemicarbazone or isatin-3-thiocarbohydrazone in methanol produced 3-substituted oxindoles in good yields. Reaction of equimolecular amounts of 5,6-diamino-urasil-solfate, trans-(1R,2R)-diaminocyclohexane, and 3,4-diamino-1,2,4-triazol-5-methyl hydrochlorid with isatin in ethanol (85%) afforded tetracyclic ring systems and ring-opened products in mild reaction conditions. |
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| Keywords: | Indolo[2,3-b]-4a,5,6,7,8,8a-hexahydroquinoxaline isatin-3-substituted pyrazino[5,6-b]pyrimidine triazolo [4,3:3′,2′]triazino[5, 6-b]indole |
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