Dapson in Heterocyclic Chemistry,Part III: Synthesis,Antimicrobial, and Antitumor Activities of Some New Bisheterocyclic Compounds Containing Biologically Active Diphenylsulfone Moiety |
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| Authors: | M M Ghorab N E Amin M S A El Gaby N M H Taha M A Shehab I M I Faker |
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| Institution: | 1. Department of Drug Radiation Research , National Center for Radiation Research and Technology (NCRRT) , Nasr City, Cairo, Egypt;2. Organic Chemistry Department, Faculty of Science for Boys , Al-Azhar Universty , Asute, Cairo, Egypt;3. Organic Chemistry Department, Faculty of Science for Girls , Al-Azhar Universty , Cairo, Egypt;4. Applied Organic Chemistry Department , National Research Center , Cairo, Egypt |
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| Abstract: | The key intermediate diisothiocyanate 2 was allowed to react with 5-amino-3-methyl-pyrazole-4-carbonitrile 3, ethyl 5-amino-1-phenyl-pyrazole-4-carboxylate 6, 2-amino-tetrahydrobenzob]thiophene-3-car-bonitrile 9, ethyl-2-amino-tetra-hydrobenzob]thiophene-3-carboxylate 12, and/or 1,2,4-triazole 15 to give the corresponding biscompounds 4, 5, 7, 8, 10, 11, 13, 14, and 16, respectively. The structure of the synthesized compounds was elucidated by elemental analyses and spectral data. Some of the prepared compounds were tested for their antimicrobial and antitumor activities. |
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| Keywords: | Antimicrobial and antitumor activities biscompounds having diphenylsulfone moiety |
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