SYNTHESE DU FOSTEDIL (4-(2-BENZOTHIAZOLYL) BENZYLPHOSPHONATE DE DIETHYLE) A PARTIR D'IMIDATES N-ACYLES |
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| Authors: | Abdallah Harizi Hédi Zantour |
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| Affiliation: | 1. Département des Sciences Fondamentales et d'Informatique, Institut Supérieur des Technologies Médicales de Tunis , Tunis, Tunisie;2. Départment de Chimie, Faculté des Sciences de Tunis, Campus Universitaire , Tunis, Tunisie |
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| Abstract: | Fostedil (diethyl 4-(benzothiazol-2-yl) benzylphosphonate) 7 has been synthesized efficiently by treatment of 2-(4-bromomethylphenyl) benzothiazole 6 with triethylphosphite. The latter (6) has been prepared by bromation of benzothiazole 3c. N-acylimidates 1(a–d) react with 2-aminobenzenethiol 2 to lead to the corresponding benzothiazoles 3(a–d) after elimination of primary amide 5. The structure of these products have been unequivocally confirmed by means of IR, 1H, 13C, and 31P NMR spectroscopy and mass spectra. |
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| Keywords: | 2-(4-Bromomethylphenyl) benzothiazole benzothiazoles diethyl 4-(benzothiazol-2-yl) benzylphosphonate Fostedil primary amide N-acylimidates |
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