SYNTHESIS OF SOME BICYCLIC OXAZOLO- AND OXAZEPINOPYRIMIDINE DERIVATIVES |
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Authors: | A Mobinikhaledi N Foroughifar B Ahmadi |
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Institution: | Department of Chemistry , Dr. Beheshti Ave, Arak, Iran |
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Abstract: | Oxazolopyrimidine compounds 2(a–c) and 3(a–e) were synthesized by a simple one-pot condensation reaction of the pyrimidine derivative 1 with 1,2-dibromoethane and 2-bromopropanoic acid, respectively. In a similar way the oxazepinopyrimidine compounds 4(a–b) were synthesized by reaction of 1 and 1,4-dichlorobutane in dioxane under reflux condition. The yields of products following recrystallization were of the order of 55–85%. |
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Keywords: | 1 2-Dibromoethane 1 4-dichlorobutane 2-bromopropanoic acid oxazepinopyrimidine oxazolo |
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