New Synthetic Routes to 1,3,4-Thiadiazole Derivatives |
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| Authors: | A. A. Elagamey F. M. A. El-Taweel R. A. N. Abu El-Enein |
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| Affiliation: | Department of Chemistry , New Damietta , Arab Republic of Egypt |
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| Abstract: | Different new 1,3,4-thiadiazolopyridine derivatives (6, 8, 20, 28, and 42) were synthesized from 5-cyanomethyl-1,3-4-thiadiazole (1) and activated nitriles. Also, spiro indolono-thiadiazolopyridine (12) was obtained from the reaction of (1) with 2-(2-oxoindolin-3-ylidene)malononitrile (10). Other heterocyclic derivatives at position-5 in the thiadiazole ring were obtained for possible use as antimicrobial agents. |
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| Keywords: | 1,3,4-Thiadiazoles actived nitriles thiadiazolopyridine pyridine furo[2,3-b]indole pyridazine |
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