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A Convenient One-Pot Synthesis of Phosphino-Dipeptide Analogs |
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| Authors: | Jean-Luc Pirat Agnes Coulombeau Arielle Genevois-Borella Henri-Jean Cristau |
| Affiliation: | 1. Laboratoire de Chimie Organique , C.N.R.S, E.N.S.C.M. , Montpellier Cedex , France;2. Centre de Recherche de Vitry-Alfortville , Aventis , Vitry-Sur-Seine , France |
| Abstract: | A general "one-pot" synthetic method is described for the preparation of phosphinodipeptides of type 1 , in 60-80% overall yield, allowing the variation of the substituents in f and/or g position to the phosphorus atom and also in f position to the nitrogen atom. |
| Keywords: | Alkyl Hypophosphite Aminoalkylphosphinic Acids Kabachnik-Fields Reaction Michael Addition Phosphinopeptides |